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The Leung Lab at the University of Pennsylvania Department of Dermatology (www.thomasleunglab.org) seeks a postdoctoral fellow and/or a senior scientist to perform research in a NIH-funded and VA-funded lab studying mammalian tissue regeneration and inflammatory skin diseases. We use molecular genetically based techniques to functionally dissect mechanisms in mice and humans, including single-cell technologies and methods to assess 3D genome architecture. We routinely interrogate diseased human skin samples to translate findings from the medical clinic to the lab. We aim to develop new therapeutic approaches in regenerative medicine and skin biology. We recently published papers demonstrating the role of aging, neuroimmune communication, and epigenetics in mammalian tissue regeneration (Nishiguchi et al., Cell Reports 2019; Wei et al., Science Immunology 2020).

The individual will have a PhD or equivalent degree and experience in molecular biology, developmental biology, immunology, gene regulation, or genomics. Helpful techniques include: animal models, flow cytometry, CRISPR, core molecular biology techniques (cloning, PCR, qPCR, chromatin immunoprecipitation, immunofluorescence, ELISA), and genomics approaches (RNA-Seq, exome sequencing, ATAC-Seq). The ideal individual should also have a strong computation background to analyze data sets from genomics studies. The individual should also be willing to work in a highly collaborative environment to support ongoing projects in the laboratory, train lab members, independently design/coordinate/execute research studies in consultation with the PI, and help in preparing manuscripts, presentations, and grant applications.

To apply, please email a letter of interest and a CV that includes three references to Dr. Leung (thl[at]pennmedicine.upenn.edu). Please include 1) a statement about your interest in our lab, 2) career goals and objectives, and 3) information about citizenship/residency/Visa status.

2021-04-30 2021-07-30

RIKEN offers up to one junior Principal Investigator (PI) position, a RIKEN Hakubi Fellow position, for an exceptionally talented female researcher for a maximum of 7 years in the framework of the Sechi Kato Program. The RIKEN Hakubi Fellow is expected to engage in creative and ambitious research in natural and mathematical sciences, including research areas bordering the humanities and social sciences, by leading her independent research team. Proposals intended to resolve urgent issues that humankind faces today are also welcome (See for example, Sustainable Development Goals of United Nations).
One of the important goals of the RIKEN Hakubi Fellows Program is to foster stimulating interactions among the Fellows with diverse backgrounds and to create an intellectual hub of scientists with different disciplines within and beyond RIKEN.

Who was Sechi Kato? – Sechi Kato (1893-1989) is a pioneering female scientist who developed spectrometric analysis of organic materials in Japan, and the first female Chief Scientist of RIKEN.

What is “Hakubi”?—Hakubi is a proverb derived from classical Chinese literature.
There were five siblings in ancient China, all excellent, but the most brilliant one had white (haku) eyebrows (bi).

Qualifications
Applicants should be talented female researchers who are able to engage in research at RIKEN on a full-time basis with the ability to manage their research laboratories as PIs. A doctoral degree is not necessarily required for this position.

Research environment
In addition to the salary, a successful candidate will be allocated a research budget of 10 to 40 million yen per year depending on the research plan and the progress. The Hakubi Fellow is assigned a laboratory space of about 150 square meters in total at Wako campus or, if considered necessary, at one of RIKEN’s branches in Japan. The final details will be decided through discussions with the Hakubi Fellows Program Head.

Term of employment and salary
Employment starts on April, 2022 or later and the contract period is up to a total of 5 years. Upon evaluation the period can be extended for additional 2 years, for a maximum of 7 years.

The annual salary is approximately 10 million yen per year (including tax). In addition, commuting and housing allowances are provided according to the RIKEN regulations.

Application and screening procedures
See our website for details: https://www.riken.jp/en/careers/programs/hakubi/sechikato2022/
Applicants of the Sechi Kato Program may also apply for the regular Hakubi Fellows Program.
The first stage of screening is an evaluation of submitted documents, the results of which is notified by early September. Successful applicants then proceed to the second stage, the interview, which is currently scheduled to take place in autumn.

Deadline
Online registration: 24:00 (JST), June 16, 2021
Upload of application documents: 15:00 (JST), June 30, 2021

Contact Information
RIKEN Hakubi Desk,
Research Personnel Affairs Section, RIKEN
hakubi[at]riken.jp

2021-04-27 2021-06-16

RIKEN offers junior Principal Investigator (PI) positions, the RIKEN Hakubi Fellows, for exceptionally talented researchers for a maximum of 7 years. RIKEN Hakubi Fellows are expected to engage in creative and ambitious research in natural and mathematical sciences, including research areas bordering the humanities and social sciences, by leading their independent research teams. Proposals intended to resolve urgent issues that humankind faces today are also welcome (See for example, Sustainable Development Goals of United Nations).
One of the important goals of the RIKEN Hakubi Fellows Program is to foster stimulating interactions among the Fellows with diverse backgrounds and to create an intellectual hub of scientists with different disciplines within and beyond RIKEN.
Up to two Hakubi Fellow positions are offered this year.

What is “Hakubi”?—Hakubi is a proverb derived from classical Chinese literature. There were five siblings in ancient China, all excellent, but the most brilliant one had white (haku) eyebrows (bi).

Qualifications
Applicants should be talented researchers who are able to engage in research at RIKEN on a full-time basis with the ability to manage their laboratories as PIs. A doctoral degree is not necessarily required for this position.

Research environment
In addition to the salary, a successful candidate will be allocated a research budget of 10 to 40 million yen per year depending on the research plan and the progress. The Hakubi Fellow is assigned a laboratory space of about 150 square meters in total at Wako campus or, if considered necessary, at one of RIKEN’s branches in Japan. The final details will be decided through discussions with the Hakubi Fellows Program Head.

Term of employment and salary
Employment starts on April, 2022 or later and the contract period is up to a total of 5 years. Upon evaluation the period can be extended for additional 2 years, for a maximum of 7 years.

The annual salary is approximately 10 million yen per year (including tax). In addition, commuting and housing allowances are provided according to the RIKEN regulations.

Application and screening procedures
See our website for details: https://www.riken.jp/en/careers/programs/hakubi/hakubi2022/
The first stage of screening is an evaluation of submitted documents, the results of which is notified by early September. Successful applicants then proceed to the second stage, the interview, which is currently scheduled to take place in autumn.

Deadline
Online registration: 24:00 (JST), June 16, 2021
Upload of application documents: 15:00 (JST), June 30, 2021

Contact Information
RIKEN Hakubi Desk,
Research Personnel Affairs Section, RIKEN
hakubi[at]riken.jp

2021-04-27 2021-06-16

There is an exciting new opportunity at the University of Southern California for highly motivated postdoctoral candidate(s) committed to developing a successful career in chromatin biology or stem cell biology. Our lab has extensive expertise and excellent track record in studying epigenetic regulations of cell fate determination using embryonic stem cell, or cancer cell as the model. We employ multidisciplinary approaches to understand the functions of histone modifying enzymes in a variety of physiological and pathological processes.

Responsibilities include a) Developing novel approaches to characterize epigenomes in stem cells and cancer cells, b) Conducting cellular, molecular and in vivo experiments for hypothesis-driven research, and c) Preparing presentations and publishing scientific manuscripts under the direction of the Principal Investigator. Candidate will enjoy a highly collaborative environment in Dou lab as well as USC research community. It is essential that the applicant has excellent organizational and communication skills. The postdoctoral trainees will be encouraged to submit their own fellowship and grant applications during their periods of training.

Applicants should hold a PhD or be close to the completion of a PhD. Degree in Molecular and Cellular Biology, Genetics, Developmental Biology, or in a relevant field. Experience with standard molecular and cellular biology techniques and familiarity with genomic technologies are essential. Experience in performing epigenomic assays (CRISPR/Cas9, ChIP-, ATAC-, 4C-seq) will be a plus but not required. The ability to learn new techniques quickly and a strict attention to details of experimental protocols are required.

Interested candidates should send a CV to Dr. Dou (yalidou[at]usc.edu), Professor of Medicine and Co-leader of the Genomic and Epigenomic Regulation Program in the USC/Norris Comprehensive Cancer Center.

Representative publications (2018-2021):

Histone acetyltransferase MOF regulates quiescence in ground-state pluripotency through fatty acid oxidation. Cell Stem Cell, 27(3):441-458, 2020.

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome. Nature Communication, 10(1):5540. doi: 10.1038/s41467-019-13550-2, 2019.

Facile target validation in an animal model using monobodies. Nature Chemical Biology, 14(9), 895-900, 2018.

HOXA9 reprograms the enhancer landscape during leukemic transformation. Cancer Cell, 34, 643-658, 2018.

2021-04-15 2021-07-15

We are seeking highly motivated candidates with interests in regenerative biology to join Dr. Huang’s laboratory at UCSF (website: http://www.cvri.ucsf.edu/~huang/lab/Research.html). The laboratory uses the heart as a model system to investigate organ development, regeneration and repair in adult zebrafish, neonatal and adult mice, with an emphasis on the pathways that regulate resident stem cell activation and mature cell dedifferentiation/proliferation, and with innovative and integrated approaches in single cell analysis, advanced imaging microscopy and genome manipulation technology.

Research Directions

1. Developing novel intravital imaging in live animals and tissue clearing techniques for high-resolution visualization of cellular behavior, activity and interaction during heart development and regeneration.

2. Performing functional screens to induce adult mouse and human cardiomyocyte regeneration using both candidate gene and directed evolution approaches integrated with CRISPR/Cas9 genome manipulation technology.

3. Taking pharmacological and genetic approaches to uncover the unifying principle governing the decline of regenerative potentials in adult mammalian organs and appendages including the heart, digit/limb, skin, brain, and spinal cord.

4. Leveraging the power of phylogenetic screen to identify novel mammalian animal models with extraordinary tissue regenerative capacity.

5. Investigating human genetic mutations and underlying molecular mechanisms in rare heart diseases that may result in preservation of cardiac regenerative potential.

6. Exploring the molecular basis of extreme biology in invertebrate and vertebrate species including water bears, naked mole-rats and ground squirrels.

We invite candidates with a highly productive training record, strong research motivation, and extensive experience in any of but not limited to the following areas: (1) developmental and regenerative biology, (2) heart physiology and cardiomyocyte biology, (3) cell division, signaling, and bioinformatics data analysis. Successful candidate will work in a highly interdisciplinary research program that interfaces developmental and stem cell biology, regenerative medicine, and cardiovascular diseases.
To apply, interested candidates should submit a single PDF file including 1) a cover letter with a brief statement of research experience, interest, and career plan, 2) curriculum vitae, and 3) a list of three references to Dr. Huang(Guo.Huang[at]ucsf.edu).

Selected publications

1. Hirose, K., Payumo, A., et al. & Huang, G. N. (2019) Evidence for hormonal control of heart regenerative capacity during the acquisition of endothermy. Science 364(6426): 184-188.

2. Payumo, A. & Huang, G. N. (2020) Lamin B2, guardian of cardiomyocyte nuclear division. Dev Cell 53:5-6

3. Huang, G. N., et al. & Olson, E. N. (2012) C/EBP transcription factors mediate epicardial activation during heart development and injury. Science 338 (6114): 1599-1603.

4. Huang, G. N., et al. and Worley, P. F. (2008) NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 319 (5862): 476-81.

Guo Huang, Ph.D.
Department of Physiology
Investigator of the Cardiovascular Research Institute
Investigator of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research

2021-04-05 2021-07-05

A postdoctoral position is available with Professor Ya-Ming Hou at Thomas Jefferson University, Philadelphia, USA. We explore tRNA epigenetic changes and how these changes control gene expression at the codon level and in response to cellular stress at the new frontier of molecular biology and the central dogma. We use a synthetic biology approach with CRISPR-edited genomes and CRISPRi approaches to determine how changes in tRNA epigenetics impact cell fitness in human health and disease. We have an intellectually stimulating environment and we encourage global networking. Current projects on tRNA epigenetic biology focus on:

(1) response to environmental stress

(2) discovery of new bacterial physiology and antibiotic therapeutics

(3) neurodegenerative and mitochondrial diseases

For more information, please see the following publications and our website:

Nat Communications (2021). PMID: 33436566
Cell Chem Biol (2020). PMID: 32553119
ACS Catal (2020). PMID: 32904895 (Featured as the cover)
Ann Neurol (2020). PMID: 32715519
Cell Systems (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)
PNAS (2016). PMID: 27849575 (Featured in PNAS commentary)
Nat Struct Mol Biol (2016). PMID: 27571175. (Featured in Science)
Nature Communications (2015). PMID: 26009254
Chem and Biol (Cell Press) (2014). PMID: 25219964
Nature (2014). PMID: 24919148 (Featured in Nature News and Views)
Nat. Communications (2011). PMID: 21629262

https://houlaboratory.com/research
https://www.jefferson.edu/university/research/researcher/researcher-faculty/hou-laboratory.html

Candidates with a recent Ph.D. and a passion for basic research are encouraged to apply. Experience in molecular biology, enzymology, nucleic acids research, and protein purification and biotechnology is preferred.

Please send a cover letter, CV, and contact information of three references to:

Ya-Ming Hou
Professor of Biochemistry and Mol Biology
Thomas Jefferson University
233 S. 10th Street, BLSB 220
Philadelphia, PA 19107, USA
T: 215-503-4480
Email: ya-ming.hou[at]jefferson.edu

2021-03-30 2021-06-30

RIKEN is currently accepting applications for the FY 2022 Special Postdoctoral Researcher (SPDR) Program, from young, creative, independent researchers who will be a powerful force in furthering RIKEN’s research activities.

Number of openings: Around 60

Research fields:
Mathematical Sciences (pure mathematics, applied mathematics, computer science, information science, artificial intelligence, etc.), Physics I (particle, nuclear, astrophysics, etc.), Physics II (condensed matter), Chemistry, Biology (cell biology, developmental biology, plant biology, structural biology, microbiology, imaging, measuring, etc.), Medical Science (brain science, psychology, immunology, oncology, genome science, etc.) and Engineering that relate to research being conducted at RIKEN.

Qualifications:
Capable of independent and responsible pursuit of a research topic. See SPDR website for details.

Salary and benefits (FY 2020 figures):

• Annual salary paid in monthly installments of 487,000 yen (gross amount).

• Commuting allowance (actual cost up to maximum of 55,000 yen per month)

• Housing allowance (partial payment of rent)

• Research budget: 1,000,000 yen per year

• Fixed-term contract employee (3 years)

Applications will be accepted from February 1 to April 15, 2021.

Inquiry:
SPDR Desk, Research Personnel Affairs Section, RIKEN
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
Email: wakate[at]riken.jp
http://www.riken.jp/en/careers/programs/spdr/career2022/
Note: The provisions for this position are premised on RIKEN’s current budget and are subject to change with any change in the budget. Please check the website for details.

2021-03-03 2021-04-15

The GargLab in the Department of Physiology at the University of Maryland Baltimore is seeking a highly motivated scientist with a strong background in molecular biology and/or electrophysiology to join our team. Research in the lab focuses on the molecular physiology of mitochondrial proteins specifically ion channels and transporters, their role in human disease, and how different organisms adapt to defects in mitochondrial functions. We use high resolution electrophysiological, imaging and biochemical approaches to elucidate signaling pathways that are fundamental to mitochondrial bioenergetics, using diverse model systems.
Available projects include detailed investigations into the structure-function studies of Mitochondrial Calcium Uniporter and related proteins.
Located in the Howard Hall, we have access to extensive core facilities. The environment within the Department is highly collaborative, and extensive career training and mentoring is available within the department and from the Office of Postdoctoral Scholars. The department faculty is internationally recognized for membrane excitability & associated (muscle, neurological and cardiovascular) disorders, and extensive opportunities are available for collaborations. Our group is also a part of BioMet - The Center for Biomedical Engineering and Technology at UMB, and has access to multiple imaging modalities.
We are seeking exceptional individuals, with a track record of impactful publications, to join our new and highly collaborative team. Relevant areas of expertise include strong electrophysiology and/or molecular biology skills, and a strong desire to make a career in mitochondrial biology or membrane excitability. Specific knowledge of any of these areas is less critical, however, than outstanding intellectual ability and strong research and quantitative skills. These individuals will work in collaboration with an outstanding group of scientists with long-standing track records in basic and translational research. This is an excellent opportunity to learn mitochondrial patch clamp and biology, and break new grounds with high impact publications.
Interested applicants should email directly to Dr. Vivek Garg at vgarg[at]som.umaryland.edu, with a cover letter and a detailed CV (with name of the referees).

Dr. Vivek Garg
Dept. of Physiology
660 W. Redwood Street
University of Maryland School of Medicine
Baltimore, MD 21201

2021-02-01 2021-05-01